Tag Archives: back pain

Rehab Journal Review: September 2014

PLOS One, August 2014

‘Did you read my sms thoughts?’ could be a reality sometime in future.  And the future might already be partly here. “Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies” sounds like a plot that could have been straight out of a James Cameron script book. 1) “Thoughts” from a person in Thiruvananthapuram, India, were recorded by surface EEG electrodes, 2) transferred via internet to France, 3) where they were “conveyed” to 3 people via Transcranial Magnetic Stimulation 4)  and they interpreted them!!! Already received extensive media coverage though almost none referenced the original article. Immense potential for persons with communication impairments. Immense potential for ethical quagmire.

Scandinavian Journal of Medicine & Science in Sports, Sep 2014

When a BMJ blog exclaims “Plantar fasciitis- important new research”, adding “an exciting new paper that is the first of its kind and represents a new treatment approach” I thought somebody has found a solution to the problem. The original paper  though was disappointing. The authors had compared high-load strength training against usual care of shoe inserts and stretches. Primary outcome of pain related symptoms were not different in both groups at 1 month, 6 months and 12 months. None of the secondary outcomes showed benefit with the new intervention. Yet, the authors conclude that their study “adds new evidence for the positive effect of a simple, progressive exercise protocol for (plantar fasciitis)”. Lessons: 1) In “conclusions”, state facts as they are. Not the way you want them to be. 2) It’s not dishonorable to report a negative study 3) do not go by authors’ conclusions, make your own from their tables and figures. 4) Do not be swayed by high regard for Scandinavian research or BMJ.

In the last month’s review, I’d promised a gift to anyone who could identify the glaring mistakes in another article on plantar fasciitis. There was just one response, and Abhita got it right. Cheers (finally, somebody responds).

Spinal Cord, September 2014

667 We’re getting closer to thanksgiving and having more than a fair share of Turkey this month. “Can spinal cord injury patients show a worsening in ASIA impairment scale classification despite actually having neurological improvement?” ask the Turkish authors before they launch their criticism on the limitations of ASIA Impairment Scale (AIS) Classification. The case examples they argue on are not uncommon, but that does not fully justify the article. We need to remember that the AIS has its advantages in allowing for a quick clinical survey, and that the Scale has never been a comprehensive assessment tool. Nothing beats a logical, complete neurological examination. We’ve had instances of post-graduate students found wanting in final exams if they fail to think beyond AIS.  “We’re getting addicted to methods, in the process forgetting basic things that we’re supposed to do”- said Dr. Pathmeswaran, a soft spoken public health Professor from Sri Lanka in his speech at the Hyderabad Cochrane Colloquium last week. How true.

693 Can abdominal massage administered by a electromechanical device reduce chronic constipation and other bowel problems in SCI? The Dutch authors found that the answer was ‘No’. Perhaps it was an oversimplification of the neurological issue to a mechanical one?

697 Acute abdomen in a person with high SCI has the potential to send you on a wild goose chase. Guarding & rigidity, the classical signs without which the surgeon would refuse to enter the OR, would be absent. Imaging studies would be as helpful as the search operations for the missing Malaysian Airlines plane. Risk to life could be very high, as we realized the hard way in one particular instance I remember.  This Turkish single center chart review study reports an incidence of about 4% (n=9) of acute abdominal emergencies in their cohort of 237 persons with SCI over five years. Gall bladder disease was the commonest cause. High clinical suspicion is warranted when there are subtle symptoms of unexplained gastroparesis and fever.

Practice tidbits

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Workout while you work. One more of those why-didn’t-I-think-of-that innovations, the human hamster wheel might just set things in motion, literally, for the movement against ‘inactivity at workplace’.

dnews-files-2014-09-human-hamster-wheel-turns-up-670-jpg

Source: new.discovery.com

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Rehab Journal Review: July 2014

Journal of Neurosurgery, July 2014

‘A nose could grow in your back’, the creepy and till-recently unsubstantiated salvo that was used to deter people from falling prey to unscrupulous ‘stem cell treatments’ has become almost true. This is the first report of such an “occurrence of a spinal cord mass after olfactory mucosal cell transplantation in a patient with a spinal cord injury.” The tumor was excised, and its biopsy revealed “respiratory epithelium with underlying submucosal glands identical to that seen in normal nasal mucosa.” The lesson: please, let’s wait. Until “better understanding of how to control cell proliferation, survival, migration, and differentiation in the pathological environment to foresee or prevent uncontrolled or abnormal cell growth in human patients.” Thanks Prashanth, for sending the links.

Archives of PMR, July 2014

1289 South Indian film industry is turning back time. Once again, there are talented female actors who can sing well as well as they can act and dance. The recent hit Fy-Fy-Fy sung by actor Ramya Nambeesan is an example. Why did I go off-track? Because of this similar rhyming functional independence tool from the US for spinal cord injury, the SCI-Fi short form, which is claimed to have good good internal consistency, and minimal ceiling and floor effects. We could have a look at this, but we’ve just transitioned to SCIM-II.

Spinal Cord, July 2014

511 This review on use of catheters for clean intermittent catheterization raises more questions than providing answers. Should off-label reuse be encouraged? If yes, how frequently should the catheters be changed? How should they be cleaned/sterilized before each use? How should they be stored? Are hydrophilic self-lubricating catheters better than uncoated tubes for off-label use? What is the overall health economic benefit/liability of each option? It is a shame that in spite of the blanket encouragement for off-label re-use in our practice for more than 3 decades, we don’t have have answers to these questions, and continue based only on ‘belief’. Worse,  “off-label reuse is not supported by legal requirements in Europe or the United States, or in Australia or Canada”. Hunting for post-graduate thesis topics? Do consider these very relevant questions that need answers.

547 One more answer that is long pending: is pharmacological prophylaxis for thromboembolism necessary for everyone with acute spinal cord injury? Do benefits outweigh risks and costs? As I’d mentioned in an earlier post, in spite of the existence of this clinical equipoise, a study proposal from my colleagues was (wrongly) shot down by our institutional review board, judging that a placebo arm is unethical. Dr HS Chhabra has apparently had no such troubles in getting approval for this RCT comparing LMWH Vs ‘No treatment’ in acute SCI. There was no difference between the two arms in the incidence of symptomatic DVT or complications, though the control arm had more asymptomatic DVT, which is of uncertain clinical significance. Hmm… one more clinically relevant thesis topic, awaiting a samaritan.

Lancet, 24 July 2014

Online “Elementary” Holmes would have remarked if he’d read this article. The RCT, comparing paracetamol Vs placebo for low back pain, is an example for how a seemingly simple study could get primetime spotlight if 1) there is real clinical relevance (I’m itching to use that ‘equipoise’ word again) 2) the publisher or the author has  good media relations. Should we continue to use paracetamol? Of course, yes, because it is at least “as good as placebo“.

BMJ, July 2014

Is Dabigatran really that good? Surprise (er…should we really be?)! One more instance of a drug company that has suppressed trial data to improve income. Internal documents accessed through a lawsuit found that “Optimally used (=titrated) dabigatran has the potential to provide patients an even better efficacy and safety profile than fixed dose dabigatran and also a better safety and efficacy profile than a matched warfarin group”. But, “Boehringer Ingelheim, the maker of dabigatran, has failed to share with regulators information about the potential benefits of monitoring anticoagulant activity”, in order not to dilute the marketing USP- ‘use without testing INR’. Lesson for our practice: Do use Dabigatran, but with INR checks to titrate dose for better effectiveness and to reduce bleeding risks.

Practice tid-bits

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